The 10 Best Estrogen Blockers to Buy 2025

If too little testosterone is being produced by the male body we will try to find the underlying cause. Medical issues such as thyroid dysfunction, pituitary tumors and iron storage diseases can cause reduced testosterone levels. Due to the individual differences in aromatase activity in men, therapy for high estrogen levels must be individualized. There is no one size fits all solution in hormone therapy so beware of cookie cutter approaches by non-expert physicians. A small amount of testosterone is converted to estradiol by aromatase, an enzyme located in fat cells. Estradiol also travels via the blood stream and needs to bind to estrogen receptors in order to exert it’s hormonal effects.

How do aromatase inhibitors interact with other medications or supplements commonly used by men?

We recently reported that hypogonadal men and post-menopausal Dianabol 10 mg P&B Labs buy online women at the opposite end of E2 spectrum have higher fat mass (40, 41). Furthermore, estrogen receptor alpha expression (ERα) decreases with increasing fat mass in men with low testosterone (41). We thus believe that men with high fat mass and hyperestrogenemia are resistant to estrogen action, as described by Schenider et al. (42) and supported by the lower expression of ERα in adipose tissues (41). It is possible that the reversal of hyperestrogenemia in severely obese hypogonadal men, improves estrogen sensitivity and favors higher fat mass loss, as experienced by our AI+WL group. In our study the significant difference in LDL changes between the two groups is mainly due to the substantial drop (27.5%) in LDL in the PBO+WL group which we believed as mostly due to weight loss.

Muscle Strength and Symptoms of Hypogonadism

In addition, estrogens are critical for functional and organizational roles in brain development and adult behavior. Although scientists have investigated aromatase, they do not yet understand the full functions of this enzyme in the adult brain. “I usually wait until someone comes to me with symptoms of high estrogen before I prescribe anastrozole,” says Rambhatla. James R. Staheli, D.O., is the Medical Director for Broad Health, Hone Health’s affiliated medical practice, and a family medicine doctor, with a specialization in men’s hormone health. Dealt with the experimental materials, analyzed the data and wrote the manuscript.

  • By inhibiting the aromatase enzyme, these ingredients prevent testosterone from converting into estrogen in a man’s body.
  • Randomization effectively generated three groups that were similar in their baseline glycemic parameters.
  • Synthetic AIs may cause decreased bone mineral density, osteoporosis, and increases in musculoskeletal disorders 55, 65, 66, 73–75.
  • Proper estrogen balance is crucial for hardcore gains, and this supplement is specially formulated to support hormonal balance and inhibit the body’s conversion of testosterone into estrogen (i.e. reduces aromatization).

The most widely used medication to manage estrogen levels during TRT is Arimidex. Aromatase acts upon testosterone and breaks it down by a process called aromatization into estradiol (a form of estrogen). The aromatase enzyme has found to be present in the testicles, brain, fat tissue, muscle, hair, and vascular tissues. Sexual desire is an androgen dependent process, principally a result of testosterone. It is believed that the ratio of testosterone to estrogen is the important factor in male sexual behavior rather than the presence of one individual hormone alone. In an interesting observational study in men who do not have the aromatase enzyme (aromatase-deficient men), estrogen supplementation increased sexual behavior.

With all of that stated, there are some men who experience moodiness, decreased libido, excessive water retention, and gynecomastia (growth of breast tissue) which are classic signs of high estrogen. Sometimes these effects subside as the body reaches homeostasis and only exist when TRT is started and both testosterone and estrogen begin to rise. However, there are some men who do need to manage estrogen even after the 6 week mark when their body reaches homeostasis. I’ll now provide a framework to follow BEFORE administering AI’s and only after these steps are undertaken (or while the steps are being undertaken). Also, I encourage men to join a clinic like Steel Health and Hormones where we corroborate your symptoms with bloodwork.